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How we grade weight-loss peptides

One yardstick for every peptide: what happened to people in controlled trials.

The evidence grade

A
Strong evidence 5 on the list

At least two positive phase 3 randomized trials for weight, and approved for weight management by Health Canada or another major regulator.

B
Promising 3 on the list

A positive phase 2 or phase 3 randomized trial for weight, but not approved for weight management yet.

C
Weak or indirect 2 on the list

Small human studies, or studies that measured something other than weight (belly fat in one patient group).

D
No human evidence 5 on the list

Animal or cell studies only, no human weight data, or human trials that failed.

A grade measures how sure we can be that a peptide causes weight loss in people. It is not a measure of how much weight it takes off, and it is not a safety rating. A drug can earn an A and still be the wrong choice for you.

What each column means

  • Weight loss: the average percentage of body weight lost at the highest tested dose in the main trial, as the journal reports it. We name the trial, its length and its size, and the full guides show the placebo result too.
  • Time to full effect: roughly when weight loss levelled off in that trial, and when people first started to see a change.
  • How you take it: the route and how often. "Easy" means a pre-filled pen or a simple pill. "Some rules" means a pill with conditions, such as an empty stomach. "Fiddly" means a vial you mix and draw up yourself.
  • Cost per month: Canadian cash price before insurance, from the sources we cite. Prices are labelled audited or estimated, as their source labels them. We never call a price verified.
  • Health Canada: whether the product is authorized in Canada, and for what. "Not authorized" means it cannot legally be sold here for people.

How we price

Prices are Canadian cash prices for one pack, including the pharmacy's dispensing fee, before any insurance. They come from one pricing dataset run across every province and the big pharmacy chains. Where a published retail phone audit (August 2026) covers a drug at a chain, the drug price comes from that audit and the row says "Audited".

Everywhere else the price is modelled from the list price and the chain's dispensing fee, and the row says "Estimated". Nobody on our team has phoned a pharmacy, so we never call a price verified. Your pharmacy's price can differ, so confirm it before you fill a prescription.

How the table is sorted

By grade first, then by the size of the weight loss in the main trial. You can re-sort by any column.

What we leave out

We do not grade products from anecdotes, before-and-after photos, clinic testimonials or forum posts. We do not publish doses for unauthorized peptides. Every number on the site traces to a numbered source; see our editorial policy.